The role of the ret proto-oncogene in human disease.
نویسنده
چکیده
The ret proto-oncogene encodes a receptor tyrosine kinase with a cadherin-like motif in the extracellular domain. Recently, it turned out that ret is the causative gene for the development of multiple endocrine neoplasia (MEN) type 2A and type 2B and Hirschsprung's disease. MEN 2A and MEN 2B mutations represent activating changes of ret whereas Hirschsprung mutations inactivate ret. In addition, another activating change of ret was found in papillary thyroid carcinoma, particularly in those cancers which developed in children from areas contaminated by the Chernobyl accident. This review summarizes the role of ret in the development of human disease.
منابع مشابه
RET proto-oncogene mutations in the diagnosis of medullary thyroid cancer: a review article
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ورودعنوان ژورنال:
- Nagoya journal of medical science
دوره 60 1-2 شماره
صفحات -
تاریخ انتشار 1997